Endocrine Abstracts

Introduction: Islet transplantation (ITx) is a therapeutic option for patients with Type 1 diabetes. However there is attrition of graft function and the majority of patients require exogenous insulin injections and/or further transplants, within five years. Mouse models help elucidate mechanisms of islet graft failure and the NOD/Lt-scid IL2rγnull (NSG) mouse is useful to study human islet engraftment but few published studies exist. As diffe...